Director: Gary Schwartz, PhD
Operations Director: Licheng Wu, MD
Location: Golding 501
Request Services: licheng.wu@einstein.yu.edu
The Einstein Animal Physiology Core assists biomedical investigators in the in vivo assessment of glucose and fatty acid metabolism, insulin sensitivity and energy homeostasis in mice and rats. The Animal Physiology Core offers a wide range of specialized, high quality methodologies and tools relevant to understanding the behavior and physiology mediating the relationships among diabetes, nutrient sensing, obesity and diabetic cardiovascular complications in rodents.
Objectives
- Advise investigators in designing metabolic studies relevant to the control of glucose homeostasis and insulin action in rodents.
- Make available to investigators specialized measurements of the following:
- Whole body and tissue-specific glucose sensitivity and insulin action in rodent models including, but not limited to insulin, pancreatic and hyperglycemic clamp studies.
- Rodent adipose tissue distribution using microCT and measurements of glycogen in liver and muscle, intrahepatic lipids and intramyocellular lipids using NMR.
- Provide specialized surgical models for the study of insulin sensitivity, energy balance, and glucose and fatty acid metabolism.
- Offer instruction to students, postdoctoral fellows, investigators and technical staff in performing surgical and physiological techniques necessary to evaluate the control of glucose homeostasis and insulin action.
- Analyze whole body carbohydrate/fatty acid oxidation, energy expenditure, feeding behavior, and locomotor activity using specialized metabolic (indirect calorimetry) and behavioral rodent cages.
- Assess the effects of spontaneous (running wheel) or scheduled (treadmill) exercise on glucose homeostasis and metabolism.
- Perform quantitative analyses of cardiac ischemia reperfusion injury and autonomic neuropathy.
Services
- In vivo assessment of insulin sensitivity and action, energy balance, and exercise. These assessments are augmented by the new surgical procedures permitting selective targeting of brain and peripheral nervous system and intestinal sites.
- Measurement of body fat composition/distribution, CNS energy and glucose utilization using a variety of non-invasive imaging modalities.
- Assessment of cardiac physiology in various experimental and therapeutic intervention models of diabetes and obesity.
Fee Schedule
All fees are per rodent.
Type of service
|
DRC member rate
|
Non-Member rate
|
Calorimeter
|
$75
|
$150
|
Calorimetry analysis
|
$20
|
$45
|
Clamp surgery
|
$50
|
$100
|
Food reward/ day
|
$25
|
$50
|
Clamp assay:
|
-
|
-
|
With radioisotope
|
$120 ($320 w/ C14)
|
$200 ($400 w/ C14)
|
Without radioisotope
|
$40
|
$80
|
Clamp data analysis
|
$15
|
$30
|
| Oral Glucose Tolerance Test |
$25 |
$50 |
| Interperitoneal Glucose Tolerance Test |
$25 |
$50 |
| Intraperitoneal Insulin Tolerance Test |
$25 |
$50 |
Body Composition
|
$5
|
$10
|
Micro CT scan
|
$75
|
$150
|
Brain cannulation
|
$40
|
$75
|
Gastric bypass
|
$100
|
$200
|
Gut neural denervation
(include afferent/efferent, branch vagotomies, splanchnicectomy)
|
$75-$150, depending on number/ extent of denervation)
|
$150 - $300
|
Exercise session (includes analysis for wheel running)
|
$30
|
$60
|
Myocardial ischemia-reperfusion
|
$200
|
$400
|
Hepatic ischemia-reperfusion
|
$200
|
$400
|
Echocardiographic assessment
|
$50
|
$100
|
Hemodynamic assessment
|
$100
|
$200
|
Implantation of blood pressure transmitters
|
$550
|
$700
|
Core Invoice
Animal Physiology Order Form
Prioritization
Use of this Core is available to investigators engaged in diabetes-related research at Albert Einstein College of Medicine and its affiliated Institutions, and to investigators at other institutions. The Core generally supports projects funded by peer-reviewed grants, generally from the NIH, ADA, or JDRF.