The overarching aim of the Clinical and Translational Investigation Core (CTIC) is to facilitate
the ability of CFAR investigators to initiate or expand HIV/AIDS research by providing
a clinical and translational research platform that creates synergy across a
wide range of disciplines. Two major Core services designed to meet
this aim are a powerful web-based
IRB compliant relational database that integrates clinical, laboratory and treatment
information from HIV inpatient and outpatient visit electronic medical records and
a CFAR biorepository of serial plasma, PBMCs and cervical-vaginal lavage fluid
samples obtained from individuals newly-diagnosed with HIV, co-infected with HIV/HCV
and elite controllers/long-term nonprogressors.
- To provide a clinical and translational
research relational database platform that enables basic, clinical, and
behavioral researchers to access and leverage our extensive range of clinical
and research cohorts for rigorous translational AIDS research.
- To provide a biorepository that supports
the research needs of CFAR investigators.
- To identify epidemiologic trends in HIV
disease outcomes in areas with high HIV prevalence by providing access to
unique prospective cohorts of HIV-infected subjects.
- To engage Bronx-based HIV community group
leaders in designing and implementing clinical research studies.
- To train early stage investigators in
AIDS clinical and translational research, including consultation on grant
- To make current and future clinical and
translational researchers aware of expertise, services, and training available
through the CTIC; and to educate local HIV clinical providers about current
evidence-based practice and new developments in HIV care.
web-based IRB-compliant relational
database that integrates clinical, laboratory and treatment information from the
electronic medical records of almost 3,000 HIV-infected individuals.
expanding biorepository of serial
plasma, PBMCs and cervical-vaginal lavage fluid samples obtained from
individuals either newly-diagnosed with HIV, co-infected with HIV/HCV and elite
broad-based CFAR Community Advisory Board consisting of leaders of a wide array
of Bronx-based HIV-related Community-based organizations that advises on how to
facilitate community-based research studies.
- A unified web-based clinical research databases that combines data from diverse cohorts and specimen repositories into one centralized relational database. The HIV Integrated Clinical Database (HICDB) provides access to the full array of clinical data for ~15,000 HIV+ and 217,000 HIV-negative patients. [For a demo of the database using screen captures, please click here. Username:dbmu\cfar and Password: D3m0S1t3 and click the red boxes.]
- The HIV Integrated Research Database (HIRDB) with Virtual Biorepository centralizes data from HIV+ research participants (and HIV-negative controls) to provide CFAR members with access to a broad-based Biobank derived from “remainder” specimens, including tissue from individuals newly infected with HIV, infected with HIV and HCV and
elite controllers as well as other biorepositories of vaginal swabs, CVL, plasma, and PBMCs
from over 300 women, including adolescents, HIV-infected and uninfected women,
pregnant women, and post-coital samples of whom a subset also provided cervical
or vaginal biopsies.
to data and samples from cohorts from Rwanda, Cameroon, Burundi and South Africa.
for the full-range of study design, initiation, implementation and evaluation
including IRB submission, processes for enabling patient recruitment,
enrollment and collection of historical information and data analysis and
Core Training Programs
- Practical issues associated with conducting
clinical and translational research
Clinical Practice (GCP),
Clinical Laboratory Practice (GCLP)
data safety and monitoring boards
a research team
- Training in new technologies and laboratory
techniques to enhance clinical and translational relevance.
- Coordination of AIDS Center CFAR Grand Rounds
Recent Core Publications
1. Batchelder AW, Brisbane M, Litwin AH, Nahvi S, Berg KM, Arnsten JH. "Damaging what wasn't damaged already": Psychological tension and antiretroviral adherence among HIV-infected methadone-maintained drug users. AIDS Care. 2013. Epub 2013/02/15. doi: 10.1080/09540121.2013.766303. PubMed Central PMCID: PMC3740002.
2. Brust JC, Berman AR, Zalta B, Haramati LB, Ning Y, Heo M, van der Merwe TL, Bamber S, Moll AP, Friedland GH, Shah NS, Gandhi NR. Chest Radiograph Findings and Time to Culture Conversion in Patients with Multidrug-Resistant Tuberculosis and HIV in Tugela Ferry, South Africa. PLoS ONE. 2013;8(9):e73975. Epub 2013/09/17. doi: 10.1371/journal.pone.0073975. PMCID: PMC3765317.
3. Cooperman NA, Shastri JS, Shastri A, Schoenbaum E. HIV Prevalence, Risk Behavior, Knowledge, and Beliefs Among Women Seeking Care at a Sexually Transmitted Infection Clinic in Mumbai, India. Health care for women international. 2013. Epub 2013/05/11. doi: 10.1080/07399332.2013.770004. PubMed PMID: 23659311.
4. Cunningham CO, Giovanniello A, Kunins HV, Roose RJ, Fox AD, Sohler NL. Buprenorphine treatment outcomes among opioid-dependent cocaine users and non-users. Am J Addict. 2013;22(4):352-7. Epub 2013/06/26. doi: 10.1111/j.1521-0391.2013.12032.x. PubMed PMID: 23795874; PubMed Central PMCID: PMC3694744
5. Cunningham CO, Roose RJ, Starrels JL, Giovanniello A, Sohler NL. Prior buprenorphine experience is associated with office-based buprenorphine treatment outcomes. J Addict Med. 2013;7(4):287-93. Epub 2013/06/01. doi: 10.1097/ADM.0b013e31829727b2. PubMed PMID: 23722632; PubMed Central PMCID: PMC3737355.
6. Fatahzadeh M, Schlecht NF, Chen Z, Bottalico D, McKinney S, Ostoloza J, Dunne A, Burk RD. Oral human papillomavirus detection in older adults who have human immunodeficiency virus infection. Oral surgery, oral medicine, oral pathology and oral radiology. 2013;115(4):505-14. Epub 2013/02/05. doi: 10.1016/j.oooo.2012.11.004. PubMed PMID: 23375488.
7. Herold BC, Keller MJ, Shi Q, Hoover DR, Carpenter CA, Huber A, Parikh UM, Agnew KJ, Minkoff H, Colie C, Nowicki MJ, D'Souza G, Watts DH, Anastos K. Plasma and mucosal HIV viral loads are associated with genital tract inflammation in HIV-infected women. J Acquir Immune Defic Syndr. 2013;63(4):485-93. Epub 2013/04/18. doi: 10.1097/QAI.0b013e3182961cfc. PubMed Central PMCID: PMC3706034.
8. Kuniholm MH, Anastos K, Kovacs A, Gao X, Marti D, Sette A, Greenblatt RM, Peters M, Cohen MH, Minkoff H, Gange SJ, Thio CL, Young MA, Xue X, Carrington M, Strickler HD. Relation of HLA class I and II supertypes with spontaneous clearance of hepatitis C virus. Genes and immunity. 2013;14(5):330-5. Epub 2013/05/03. doi: 10.1038/gene.2013.25. PubMed PMID: 23636221; PubMed Central PMCID: PMC3723800.
9. Kuniholm MH, Parrinello CM, Anastos K, Augenbraun M, Plankey M, Nowicki M, Peters M, Golub ET, Lurain N, Landay AL, Strickler HD, Kaplan RC. Hepatitis C viremia is associated with cytomegalovirus IgG antibody levels in HIV-infected women. PLoS ONE. 2013;8(4):e61973. Epub 2013/04/25. doi: 10.1371/journal.pone.0061973. PubMed PMID: 23613990; PubMed Central PMCID: PMC3629158.
10. Megra B, Eugenin E, Roberts T, Morgello S, Berman JW. Protease Resistant Protein Cellular Isoform (PrP) as a Biomarker: Clues into the Pathogenesis of HAND. J Neuroimmune Pharmacol. 2013. Epub 2013/04/26. doi: 10.1007/s11481-013-9458-4. PubMed PMID: 23616272.
11. Shapiro ME, Mahoney JR, Peyser D, Zingman BS, Verghese J. Cognitive Reserve Protects Against Apathy in Individuals with Human Immunodeficiency Virus. Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists. 2013. Epub 2013/09/12. doi: 10.1093/arclin/act071. PubMed PMID: 24021844.