Wilf Family Cardiovascular Research Institute

Yun Chen, Ph.D.

Yun Chen, Ph.D.Yun Chen, Ph.D.
Research Assistant Professor, Department of Medicine (Cardiology) 

Dr. Yun Chen's research seeks to understand the mechanism of programmed apoptotic and necrotic cell death, mitochondrial dynamics and quality control, as well as chaperon-mediated autophagy in cell survival. He has been studying molecular mechanisms of mitochondrial mediated apoptosis, necrosis and autophagy in heart. full bio>> 

Key Publications

  1. Moshi Song, Katsuyoshi Mihara, Yun Chen, Luca Scorrano, and Gerald W Dorn II. Mitochondrial fission and fusion factors reciprocally orchestrate mitophagic culling in mouse hearts and cultured fibroblasts. Cell Metabolism 2015; 21(2):273-85.
  2. Yun Chen and Gerald W. Dorn II. Mitofusin 2 is a Parkin Receptor for Culling Damaged Mitochondria. Science 2013; 34: 471-475.
  3. Yun Chen, György Csordás, Casey Jowdy, Timothy G. Schneider, Wei Wang, Yingqiu Liu, Michael Kohlhaas, Maxie Meiser, Jeanne M. Nerbonne, Christoph Maack, and Gerald W. Dorn II. Mitofusin 2-containing mitochondrial-reticular microdomains regulate organelle Ca2+ crosstalk in mouse and Drosophila hearts. Circulation Research. 2012; 111(7): 863-875.
  4. Yun Chen, Yingqiu Liu, and Gerald W Dorn II. Mitochondrial fusion is essential for organelle function and cardiac homeostasis. Circulation Research 2011; 109(12):1327-1331.
  5. Yun Chen, Abhinav Diwan, Emily H. Cheng, Scot J. Matkovich and Gerald W. Dorn II. Dual Autonomous Mitochondrial Cell Death Pathways are activated by Nix/BNip3L and Induce Cardiomyopathy. Proc Natl Acad Sci USA (feature article), 2010; 107(20): 9035-9042.
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