Wilf Family Cardiovascular Research Institute

Robert C. Kaplan, Ph.D.

Robert C. Kaplan, Ph.D.Robert C. Kaplan, Ph.D.
Professor, Department of Epidemiology & Population Health
Dorothy and William Manealoff Foundation and Molly Rosen Chair in Social Medicine

Dr. Robert Kaplan is an epidemiologist with expertise in cardiovascular disease, diabetes, obesity and other metabolic conditions. His major projects and roles include Steering Committee chair and PI of the Hispanic Community Health Study/Study of Latinos (HCHS-SOL) cohort of 16,425 Hispanic/Latino adults, the largest long-term study of Hispanics ever conducted in the U.S. He has extensive experience with longitudinal cohort studies on cardiometabolic disease funded by NHLBI and NIDDK, including the NIH Cardiovascular Health Study, CHS, and considerable experience in genomic epidemiology (genetics, transcriptomics, etc.). full bio>> 


Principal Investigator, Role of innate immunity in HIV related vascular disease: biomarkers & mechanisms
PI: Kaplan
NIH/NHLBI (1R01HL126543)
$3,431,987 (total)
This proposal will a) identify mechanisms linking innate immunity with CVD in the setting of chronic, treated HIV infection; b) develop novel serum biomarkers for monocyte/macrophage related inflammation and coagulation that may stratify CVD risk in the HIV-infected population; c) use global sequencing of RNAs (RNA-Seq) to define HIV- and CVD-associated gain and/or loss of function of specific signaling pathways by studying CD14++ and CD14+CD16+ monocyte subsets from well-characterized HIV+ and HIV- patient groups from the WIHS and MACS NIH cohorts

Bronx Field Center, Hispanic Community Health Study
PI: Kaplan
NIH/NHLBI (HHSN268200625235C)
$15,734,093 (total)
The overall goal of this project is to recruit 4,000 Hispanic/Latino adults 18-74 years of age in Bronx NY and obtain long-term followup on CVD, asthma, COPD, diabetes, cancer, and other health outcomes, as part of the multicenter Hispanic Community Health Study.

Hispanic Community Children's Health: Study of Latino Youth (Co-investigator)
PI: Isasi
NIH/NHLBI (1R01HL102130-01)
The "SOL-Youth" project is an ancillary study to the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), which will enroll children of HCHS/SOL participants. The study will examine a wide range of socio-cultural factors and biological markers associated with obesity in a sample of 1,600 Latino boys and girls aged 8-14 years old from the Bronx, NY; Chicago, IL; Miami, FL and San Diego, CA.

Epidemiologic Determinants of Cardiac Structure and Function among Hispanics (Co- investigator/Site PI)
PI: Rodriguez
NIH /NHLBI (1R01HL104199-01)
This multicenter study will comprehensively evaluate left ventricular mass, geometry, systolic function and diastolic function using novel techniques in a unique nationally representative cohort of Hispanics.

CVD and inflammation across the lifespan in HIV infected adults and children
$363,508 (total)
PI: Kaplan/Delaney (MPI)
NIH/NHLBI (1R21HL120394-01)
This study will clarify associations between vascular disease and HIV-related and traditional CVD risk factors in HIV-infected persons across a wide spectrum of age, building upon a unique consortium of multiple HIV-infected and HIV-uninfected cohorts.

Genetic and epidemiologic predictors of glucose homeostasis measures in Hispanics
$10,765,189 (total)
PI: Kaplan/Rotter/Wagenknecht
NIH/NIDDK (R01 DK085175-11A1)
The GUARDIAN Consortium (Genetics Underlying Diabetes in Hispanics) has the following goals: (1) to perform a GWAS to detect loci underlying variation in glucose homeostasis traits in a multi-cohort pedigree-based set of 4685 Hispanics; (2) to translate/extend these findings to the relevant clinical disease, T2DM, by testing for association in a set of ~3500 T2DM cases and ~5500 controls; and (3) to sequence up to 12 genetic loci from our GWAS in order to identify specific variants contributing to variation in glucose homeostasis traits and susceptibility to T2DM. This project uses data from the Hispanic Community Health Study.

A Study of the Natural History of HIV Infection in Women (Co-investigator)
PI: Anastos
NIH/NIAID (7U01 AI035004-11)
The major objective of this project is to study the natural history of HIV infection in women.

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