Wilf Family Cardiovascular Research Institute

Peng Wu, Ph.D.

Peng Wu, Ph.D.Peng Wu, Ph.D.
Associate Professor, Department of Biochemistry 

Dr. Wu's research integrates synthetic chemistry with biochemistry to explore the relevance of glycosylation in human disease. The glycome, defined as the full complement of glycans that a cell produces, is involved in a variety of physiological processes, including angiogenesis, fertilization, stem cell development and neuronal development. Changes in the glycome have also been shown to mark the onset of cancer and inflammation. The wealth of biological information encoded in the glycome has motivated Wu lab researchers to develop methods for its retrieval. full bio>> 

Key Publications

  1. Soriano Del Amo, D.; Wang, W.; Jiang, H.; Besanceney C.; Yan A.C.; Levy, M.; Liu, Y.; Marlow, F.L.; Wu, P. Biocompatible Copper(I) Catalysts for in Vivo Imaging of Glycans. J. Am. Chem. Soc. 2010, 132, 16893.
  2. Feng, L.; Jiang, H.; Wu, P., Marlow, F.L. Negative Feedback Regulation of Wnt Signaling via N-linked Fucosylation in Zebrafish. Dev. Biol. 2014, 395, 268.
  3. Nordstrøm, L.; Sironi, J.; Aranda, E.; Maisonet, J.; Perez-Soler, R.; Wu, P.; Schwartz, E. Discovery of Autophagy Inhibitors with Anti-proliferative Activity in Lung and Pancreatic Cancer Cells. ACS. Med. Chem. Lett. 2015.
  4. Wang, W.; Hu, T.; Frantom, P. A.; Zheng, T; Gerwe, B.; Soriano del Amo, D.; Seidel, R.D. III, Wu, P. Chemoenzymatic Synthesis of GDP-L-fucose and the Lewis X Glycan Derivatives. Proc. Natl. Acad. Sci. USA. 2009, 106, 16096.
  5. Zheng, T.; Jiang, H.; Gros, M., Soriano del Amo, D.; Sundaram, S.; Lauvau, G.; Marlow, F.; Liu, Y., Stanley, P.; Wu, P. Tracking N-acetyllactosamine on Cell Surface Glycans in Vivo. Angew. Chem. Int. Ed. 2011, 50, 4113.
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