Wilf Family Cardiovascular Research Institute

Dongsheng Cai, MD, PhD

Dongsheng Cai, MD, PhDDongsheng Cai, MD, PhD
Professor, Department of Molecular Pharmacology
Chair of the Institutional Review Board

Dr. Dongsheng Cai's research focuses on understanding the role of the central nervous system in the development and intervention of metabolic syndrome, aging and related diseases. full bio>> 

Key Publications

  1. Kim MS, Yan J, Wu W, Zhang G, Zhang Y, Cai D. Rapid linkage of innate immunological signals to adaptive immunity by the brain-fat axis. Nat Immunol. 2015;16(5):525-33.
  2. Yan J, Zhang H, Yin Y, Li J, Tang Y, Purkayastha S, Li L, Cai D. Obesity- and aging-induced excess of central transforming growth factor-beta potentiates diabetic development via an RNA stress response. Nat Med. 2014;20(9):1001-8.
  3. Zhang G, Li J, Purkayastha S, Tang Y, Zhang H, Yin Y, Li B, Liu G, Cai D. Hypothalamic programming of systemic ageing involving IKK-beta, NF-kappaB and GnRH. Nature. 2013;497(7448):211-6.
  4. Li J, Tang Y, Cai D. IKKbeta/NF-kappaB disrupts adult hypothalamic neural stem cells to mediate a neurodegenerative mechanism of dietary obesity and pre-diabetes. Nat Cell Biol. 2012;14(10):999-1012.
  5. Purkayastha S, Zhang G, Cai D. Uncoupling the mechanisms of obesity and hypertension by targeting hypothalamic IKK-beta and NF-kappaB. Nat Med. 2011;17(7):883-7.


  1. Glia-neuron interaction via IKK-Beta/NF-KappaB in obesity and related pre-T2D
    NIDDK/NIH, R01 DK 078750
    Role: PI
  2. Role of hypothalamic IKK -Beta/NF-KappaB in nutritional control of aging
    NIA/NIH (R01 AG 031774
    Role: PI
  3. Hypothalamic IKK-beta in obesity-related hypertension
    NHLBI/NIH, R01 HL113180
    Role: PI
  4. Hypothalamic HIF in nutrient sensing and metabolic control
    NIDDK/NIH R01 DK 099136
    Role: PI
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