Albert Einstein Cancer Center

Associations of high-grade prostate cancer with BRCA1 and BRCA2 mutations

This large study by Robert Burk and his colleagues at AECC found that men who have BRCA2 and BRCA1-185delAG mutations, that are associated with a high risk of breast cancer in women, are also at increased risk of high Gleason score prostate cancer (the subset of prostate cancers that are at high risk for progression). The data suggest that men with these mutations may require aggressive surveillance and early treatment. Further, the study raises the question of whether Ashkenazi Jewish men with a strong family history of breast and/or prostate cancer – the population with highest rates of these mutations – should undergo BRCA1/2 screening. 

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