Selected Achievements

Smith M, Choudhary GS, Pellagatti A, Choi K, Bolanos K, Bhagat T, Gordon-Mitchell S , Ahrens DV, Pradhan K, Steeples V, Kim S, Steidl U, Walter M, Fraser I, Kulkarni A, Salomonis N, Komurov K, Boultwood J*, Verma A*, Starczynowski D* U2AF1 mutations induce oncogenic IRAK4 isoforms and activate innate immune pathways in myeloid malignancies. Nature Cell Biol, 2019 (In Press) *Co Corresponding

Shenoy, N., Bhagat, T.D., Cheville, J., Lohse, C., Bhattacharyya, S., Tischer, A., Machha, V., Gordon-Mitchell, S., Choudhary, G., Wong, L.F., et al. Ascorbic acid-induced TET activation mitigates adverse hydroxymethylcytosine loss in renal cell carcinoma. J Clin Invest 130 (2019/Mar 4).  PMID: 30702441.

Carvajal, L.A., Neriah, D.B., Senecal, A., Benard, L., Thiruthuvanathan, V., Yatsenko, T., Narayanagari, S.R., Wheat, J.C., Todorova, T.I., Mitchell, K., et al. Dual inhibition of MDMX and MDM2 as a therapeutic strategy in leukemia. Sci Transl Med 10436,  (2018/Apr 11).  PMID: 29643228.

Lee, C.H., Kiparaki, M., Blanco, J., Folgado, V., Ji, Z., Kumar, A., Rimesso, G., and Baker, N.E. A Regulatory Response to Ribosomal Protein Mutations Controls Translation, Growth, and Cell Competition. Dev Cell (2018/Aug 1).  PMID: 30078730.

Suzuki, M., Liao, W., Wos, F., Johnston, A.D., DeGrazia, J., Ishii, J., Bloom, T., Zody, M.C., Germer, S., and Greally, J.M. Whole-genome bisulfite sequencing with improved accuracy and cost. Genome Res (2018/Aug 9).  PMID: 30093547.

Shah, U.A., Chung, E.Y., Giricz, O., Pradhan, K., Kataoka, K., Gordon-Mitchell, S., Bhagat, T.D., Mai, Y., Wei, Y., Ishida, E., et al. North American ATLL has a distinct mutational and transcriptional profile and responds to epigenetic therapies. Blood (2018/Aug 13).  PMID: 30104217.

Bartholdy, B., Lajugie, J., Yan, Z., Zhang, S., Mukhopadhyay, R., Greally, J.M., Suzuki, M., and Bouhassira, E.E. Mechanisms of establishment and functional significance of DNA demethylation during erythroid differentiation. Blood advances 215, 1833-1852 (2018/Aug 14).  PMID: 30061308.

Chen, J., Kao, Y.R., Sun, D., Todorova, T.I., Reynolds, D., Narayanagari, S.R., Montagna, C., Will, B., Verma, A., and Steidl, U. Myelodysplastic syndrome progression to acute myeloid leukemia at the stem cell level. Nat Med (2018/Dec 3).  PMID: 30510255.

Pinho, S., Marchand, T., Yang, E., Wei, Q., Nerlov, C., and Frenette, P.S. Lineage-Biased Hematopoietic Stem Cells Are Regulated by Distinct Niches. Dev Cell 445, 634-641 e634 (2018/Feb 9).  PMID: 29456137. PMCID: PMC5886750.

Shastri, A., and Verma, A.K. Eltrombopag reduces clinically relevant thrombocytopenic events in higher risk MDS and AML. The Lancet Haematology 51, e6-e7 (2018/Jan).  PMID: 29241763.

Kale, A., Ji, Z., Kiparaki, M., Blanco, J., Rimesso, G., Flibotte, S., and Baker, N.E. Ribosomal Protein S12e Has a Distinct Function in Cell Competition. Dev Cell 441, 42-55.e44 (2018/Jan 8).  PMID: 29316439. PMCID: PMC5784854.

Kong, Y., Berko, E.R., Marcketta, A., Maqbool, S.B., Simoes-Pires, C.A., Kronn, D.F., Ye, K.Q., Suzuki, M., Auton, A., and Greally, J.M. Detecting, quantifying, and discriminating the mechanism of mosaic chromosomal aneuploidies using MAD-seq. Genome Res 287, 1039-1052 (2018/Jul).  PMID: 29773658. PMCID: PMC6028128.

Maryanovich, M., Zahalka, A.H., Pierce, H., Pinho, S., Nakahara, F., Asada, N., Wei, Q., Wang, X., Ciero, P., Xu, J., Leftin, A., and Frenette, P.S. Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche. Nat Med (2018/May 7).  PMID: 29736022.

Drelon, C., Belalcazar, H.M., and Secombe, J. The Histone Demethylase KDM5 Is Essential for Larval Growth in Drosophila. Genetics (2018/May 15).  PMID: 29764901.

Mitchell, K., Barreyro, L., Todorova, T.I., Taylor, S.J., Antony-Debre, I., Narayanagari, S.R., Carvajal, L.A., Leite, J., Piperdi, Z., Pendurti, G., Mantzaris, I., Paietta, E., Verma, A., Gritsman, K., and Steidl, U. IL1RAP potentiates multiple oncogenic signaling pathways in AML. J Exp Med 2156, 1709-1727 (2018/May 17).  PMID: 29773641. PMCID: PMC5987926.

Willis, I.M., Moir, R.D., and Hernandez, N. Metabolic programming a lean phenotype by deregulation of RNA polymerase III. Proc Natl Acad Sci U S A (2018/Nov 14).  PMID: 30429315.

Boulais, P.E., Mizoguchi, T., Zimmerman, S., Nakahara, F., Vivie, J., Mar, J.C., van Oudenaarden, A., and Frenette, P.S. The Majority of CD45(-) Ter119(-) CD31(-) Bone Marrow Cell Fraction Is of Hematopoietic Origin and Contains Erythroid and Lymphoid Progenitors. Immunity (2018/Oct 4).  PMID: 30314756.

Kao, Y.R., Chen, J., Narayanagari, S.R., Todorova, T.I., Aivalioti, M.M., Ferreira, M., Ramos, P.M., Pallaud, C., Mantzaris, I., Shastri, A., Bussel, J.B., Verma, A., Steidl, U., and Will, B. Thrombopoietin receptor-independent stimulation of hematopoietic stem cells by eltrombopag. Sci Transl Med 10458,  (2018/Sep 12).  PMID: 30209246.