Albert Einstein Cancer Center

Host-microbiome interactions

The laboratory is focused on the study of orphan nuclear receptors, specifically the Pregnane X Receptor (PXR), that recognize xenobiotics (and endobiotics) as ligands and their effects on mammalian physiology and pathophysiology. Recently, we have shown that microbial metabolites can serve as ligands for these receptors that impact on intestinal physiology and pathophysiology (Immunity, 2014).  In recent work, we have identified new and novel bacterial species/strains from the enteric microbiota. Research is directed to studies on the importance of these species to host physiology and pathophysiology (inflammation, cancer). Studies will encompass mechanisms of host-microbe (and microbe-host) interactions and their impact on inflammation and premalignant to malignant processes. Also of interest are mechanisms of bacterial biofilms using both genetic, biochemical and biophysical approaches.  



Please e-mail your CV and cover letter focusing on your interests and goals, along with contact information (and/or letters) from three referees to:  Dr. Sridhar Mani  


Sridhar Mani

Albert Einstein Cancer Center

Albert Einstein College of Medicine

1300 Morris Park Avenue
Bronx, NY 10461 




Dr. Sridhar Mani Research Profile 




Albert Einstein College of Medicine is an equal opportunity employer committed to workforce diversity. 



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Albert Einstein Cancer Center
1300 Morris Park Avenue
Bronx, New York 10461
Telephone: 718.430.2302  

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