Albert Einstein Cancer Center

Regulation of tumor metastasis by S100A4

This laboratory focuses on the regulation of tumor metastasis by S100A4, a calcium-regulated myosin binding protein expressed in both tumor cells and cells of the immune system. We have developed a floxed S100A4 mouse that allows us to ask how S100A4 expression in stromal cells contributes to tumorigenesis and metastasis. We have identified S100A4 as a critical regulator of macrophage invasion. S100A4 acts by regulating the dynamics and degradative functions of podosome rosettes, actin-rich structures that perform adhesive and invasive functions in macrophages. We are combining cell biological and animal-based studies to define how S100A4 regulates both the actin- and microtubule-based cytoskeletons in macrophages.

The postdoctoral project is directed to how S100A4-mediated regulation of macrophage function promotes a permissive metastatic environment. The successful applicant should have strong expertise in cell biology, biochemistry and mammalian cell culture.  Experience with mouse tumor models will be an asset.

 

 

Please e-mail your CV and cover letter focusing on your interests and goals, along with contact information (and/or letters) from three referees to:  Dr. Anne Bresnick  

 

Anne Bresnick

Albert Einstein Cancer Center

Albert Einstein College of Medicine

1300 Morris Park Avenue
Bronx, NY 10461
anne.bresnick@einstein.yu.edu 

 

 

 

Dr. Anne Bresnick Research Profile 

 

 

 

Albert Einstein College of Medicine is an equal opportunity employer committed to workforce diversity. 

 

 
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Albert Einstein Cancer Center
1300 Morris Park Avenue
Bronx, New York 10461
Telephone: 718.430.2302
aecc@einstein.yu.edu  

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