Albert Einstein Cancer Center

Potential differences in gene regulation in lungs and lung tumors among individuals, using genetic and epigenetic techniques

Our translational laboratory is currently examining functional genetic and epigenetic changes at the whole genome/transcriptome level in non-malignant human lung tissue, taken from those individuals with lung cancer (cases) and those without lung cancer (controls). The post-doctoral fellow will design and execute WG bisulfite-seq, RNA-seq, microRNA-seq, in brushed human bronchial progenitor cell specimens from these two groups. We have an eye to further development of non-invasively obtained surrogate airway tissues for early detection purposes.  Newer functional epigenetic technologies developed in the lab include a strategy for recapitulation of high detail cytosine methylation patterns in chromatin and in reporter constructs, and a microRNA-mRNA binding assay.  A background in molecular biology and molecular genetics, and an ability to work independently are required.

 

Please e-mail your CV and cover letter focusing on your interests and goals, along with contact information (and/or letters) from three referees to:  Dr. Simon Spivak  

 

Simon Spivak

Albert Einstein Cancer Center

Albert Einstein College of Medicine

1300 Morris Park Avenue
Bronx, NY 10461
simon.spivak@einstein.yu.edu 

 

 

 

Dr. Simon Spivak Research Profile 

 

 

 

Albert Einstein College of Medicine is an equal opportunity employer committed to workforce diversity. 

 

 
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Albert Einstein Cancer Center
1300 Morris Park Avenue
Bronx, New York 10461
Telephone: 718.430.2302
aecc@einstein.yu.edu  

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