Albert Einstein Cancer Center

Studies on the regulation of PI 3-kinases and their role in tumorigenesis and metastasis

Our laboratory focuses on understanding the biochemical basis for PI 3-kinase regulation by receptor tyrosine kinases and GPCRs, as well as their deregulation by mutation. We have identified point mutants that specifically uncouple PI 3-kinases from distinct upstream activators. This allows us to produce animal models in which we can ask how different inputs into PI 3-kinase signaling contribute to tumorigenesis and metastasis. We are also interested in PI 3-kinase signaling to the cytoskeleton, and have identified a novel PI 3-kinase dependent pathway that regulates myosin filament assembly and tumor cell metastasis. Finally, we are studying the role of PI 3-kinase signaling in the endocytic system, particularly pathways that regulate nutrient uptake and receptor turnover and degradation.

 
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Message From the Director

I. David Goldman, M.D.

Since the start of the 20th century, scientists have sought ways of harnessing the immune system to attack cancer cells. The challenge has been enormous. The immune system is designed to destroy foreign ... 

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Statement in Support of HPV Vaccination for Cancer Prevention  
 

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Albert Einstein Cancer Center
1300 Morris Park Avenue
Bronx, New York 10461
Telephone: 718.430.2302
aecc@einstein.yu.edu  

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