Key Words: Regulation,structure/function, physiological and pharmacological roles of a proton-coupled folate transporter and the genetics of hereditary folate malabsorption
A postdoctoral position is available for studies
on the structure-function, regulation and biological/pharmacological properties
of the proton-coupled folate transporter (PCFT) cloned by this laboratory (Cell
127:917-28, 2006) and mutated in the autosomal recessive disorder, hereditary
folate malabsorption. PCFT mediates intestinal folate absorption and transport
of antifolate cancer chemotherapeutics into cancer cells within their acidic
microenvironment. Candidates should have a strong background in molecular
biology and/or physiology/electrophysiology/ homology modeling and a
track-record of productivity during their doctoral training.
Click here for a complete list of publications from this laboratory.