Institute for Aging Research

The Paul F. Glenn Center for the Biology of Human Aging

Paul F. Glenn Center for the Biology of Human Aging

The Glenn Center is the first center for research exclusively focused on the biology of human aging.

Aging is a complex, universal condition leading to functional decline of all cells and organisms, causing major public health problems at the national and global level. While our understanding of the factors affecting aging and longevity has grown precipitously, most research has been conducted mainly on experimental animal models with short life spans.

 

Research Goals

  • Uncover genetic and biological mechanisms that protect against human aging and age-related diseases 
  • Test the efficacy of the first generation of pro-longevity interventions in human aging 
  • Develop novel generations of preventive and therapeutic interventions against neoplastic and non-neoplastic cellular aging in humans 

Ongoing Studies

  1. Discovery of genetic and epigenetic markers of exceptional longevity
    Jan Vijg, PhD
    Nir Barzilai, MD
    Yousin Suh, PhD,
    John Greally, MD, BCH, PhD 
  2. Rescue of human cellular aging
    Ana Maria Cuervo, MD, PhD
    Fernando Macian, MD, PhD  
  3. Preclinical Development of vaccines against age-related diseases
    Claudia Gravekamp PhD
    Mark Einstein, MD, MS  
  4. Mechanistic human studies to investigate novel anti-aging therapies
    Meredith Hawkins, MD
    Jill Crandall, MD
    Nir Barzilai, MD  

The "Glenn 10"

Glenn Center research is carried out in the core facilities and laboratories of ten renowned Einstein investigators.

Nir Barzilai aging research albert einstein college of medicine Montefiore Medical Center Bronx NY

Nir Barzilai, MD
Professor of Medicine (Endocrinology)
Professor of Genetics
Ingeborg and Ira Leon Rennert Chair in Aging Research
Director, Institute for Aging Research

Dr. Barzilai is principal investigator of two program projects, the T32 aging training grant, and several independent grants from the NIA and other sources of aging research funding. He is a recipient of several awards, most notably, the Beeson Physician Faculty Scholar Award (1997-2000), Ellison Medical Foundation Senior Scholar (2000-2005), the Nathan W. Shock Award Lecture (2003), the Paul Glenn Award, and the 2010 Irving S. Wright Award of Distinction. Dr. Barzilai's research has been repeatedly featured in The New York Times, USA Today, The Washington Post, The Wall Street Journal, and in media programs such as NOVA, PBS and CBS.


Jan Vijg PhD aging research albert einstein college of medicine Montefiore Medical Center Bronx NY

Jan Vijg, PhD
Professor, Department of Genetics
Professor, Department of Ophthalmology & Visual Sciences
Chair, Department of Genetics
Lola and Saul Kramer Chair in Molecular Genetics

Dr. Vijg received his Ph.D. at the University of Leiden, The Netherlands, in 1987. From 1990 to 1993, he was founder and Scientific Director of Ingeny B.V., a Dutch Biotechnology company. In 1993, he moved to Boston to take up a position as Associate Professor of Medicine at Harvard Medical School. In 1998, he accepted an offer from the University of Texas Health Science Center in San Antonio, Texas to become a Professor in the Department of Physiology. From 2006 to 2008, he was a Professor at the Buck Institute for Age Research in Novato, California. With his research team, he was the first to develop transgenic mouse models for studying mutagenesis in vivo (in 1989) and has used these models ever since in studying the relationship between damage to the genome and aging. He has published over 200 scientific articles and two books, and is inventor or co-inventor on eight patents.


Ana Maria Cuervo MD PhD aging research albert einstein college of medicine Montefiore Medical Center Bronx NY

Ana Maria Cuervo, MD, PhD
Professor of Medicine (Gastroenterology & Liver Diseases)
Professor of Developmental & Molecular Biology
Professor of Anatomy & Structural Biology
Robert and Renée Belfer Chair for the Study of Neurodegenerative Diseases
Co-Director, Institute for Aging Research

Dr. Cuervo has extensive experience in the study of cellular homeostasis with emphasis on the autophagic system. Her honors include the Ellison Medical Foundation New Scholar (2002-2006), the 2006 Nathan W. Shock Award lecture, the 2008 Cristofalo Rising Start Award in Aging Research, the 2009 Roy Walford Endowed Lecture on Aging, the 2010 Beneett J. Cohen award as a leader in basic aging biology, and the 2011 Cherkin Award Lecture in gerontology. She is co-Editor-in Chief of Aging Cell since 2006, and has been elected as member of the NIH/NIA scientific council.

Fernando Macian, MD, PhD
Associate Professor of Pathology

Dr. Macian has been studying the regulation of T lymphocyte function in the immune system for more than 15 years and uses this expertise to analyze the mechanisms that underlie the defects in the immune responses that occur with age. Dr. Macian received an Irene Diamond Research Scholar award in Immunology (2004-2007) and is a member of the National Scientific Advisory Council of the American Federation for Aging Research.


Yousin Suh, PhD
Associate Professor of Genetics and Medicine (Endocrinology)

Dr. Suh is a human geneticist who has shown the ability of identifying mutations or polymorphisms related to aging and its disease and finding their functional meaning. She is the first to discover functional mutations in the IGF-1 receptor in human centenarians (PNAS), linking the pathway that was previously was relevant to lower species. Similarly, she has shown the role of telomere length and the genomic of the telomerase genes in in centenarians (PNAS). She has received numerous grant and awards and is central partner in two program projects.


John Greally, MD, BCH, PhD Associate Professor of Genetics (Division of Computational Genetics), Pediatrics (Division of Genetics), and Medicine (Division of Hematology)
Dr. Greally’s research is in the area of epigenomic regulation of the genome, and its dysregulation in disease. He is the founding director of the Einstein Center for Epigenomics, and his research includes studies of the epigenetic regulation of stem cell differentiation and transcription-targeted cytosine methylation, and epigenetic abnormalities in human diseases such as type II diabetes mellitus, infection, and allergies. His aging research is focused on the influence of prenatal events on the epigenome and how these may influence age-related diseases, and is a partner in establishing the epigenetics of exceptional longevity. He also performs clinical duties at the Children’s Hospital at Montefiore as a Clinical Genomicist, seeing patients who have been tested with new genome-wide technologies.


Claudia Gravekamp PhD
Associate Professor in the Department of Microbiology and Immunology
Member, Albert Einstein Cancer Center
Dr. Gravekamp was trained as a tumor immunologist and has broad experience in the development and testing of cancer vaccines in preclinical animal models and human cells. Her most recent work is focused on developing Listeria-based vaccines that are effective against metastatic cancer specifically in older people. She has authored 50 publications, and has served as reviewer on several NIH study sections (NNCAM, SBIR, CII). As PI on several university- and NIH/NCI/NIA-funded


Mark Einstein, MD, MS
Associate Professor, Obstetrics & Gynecology, Women’s Health, Epidemiology & Population Health
Dr. Einstein has been the lead investigator for numerous multi-institutional therapeutic and diagnostic clinical trials with therapeutics for gynecologic malignancies as well as gynecologic cancer prevention. He is also the clinical lead in a study of uterine cancer therapy targets that is utilizing the NCI-funded Gynecologic Oncology Group (GOG) uterine tumor bank. He is the Co-Chair of the GOG Immunotherapy Committee and a member of the GOG Cervix Committee and is a member of the NCI-funded Cancer Genome Atlas Project Cervix Working Group. He serves on the Board of Directors of the American Society for Colposcopy and Cervical Pathology (ASCCP) and the Board of Directors for the Foundation for Women’s Cancers.


Jill Crandall, MD
Professor of Clinical Medicine
Director of the Diabetes/Endocrinology Clinical Trials Unit
Dr. Crandall serves as Principal Investigator for several NIH-sponsored clinical trials including the Diabetes Prevention Program, the Epidemiology of Diabetes Interventions and Complications (EDIC) study and the Testosterone Trial. She is co-director of the Clinical Research Methodology Unit of the Diabetes Research & Training Center and Clinical Core director for the LonGenity Study of the genetic basis for exceptional longevity. Her research interests focus on age-related changes in glucose metabolism and the relationship between hyperglycemia and cardiovascular risk. She is associate editor for the Journal of Gerontology Series A Biological and Medical Sciences.

Meredith Hawkins, MD Professor of Medicine
Director of the Global Diabetes Initiative
Challenging the 'insulin-centric' view of hepatic glucose metabolism, Dr. Hawkins has highlighted the importance of defective 'glucose effectiveness' to suppress glucose production in diabetes mellitus, and has provided the first evidence in humans for central regulation of glucose production. Her honors include the Beeson Physician Faculty Scholar Award (2003-6), the Clinical Associate Physician Award from the NIH (2000), the Junior Physician Scientist Award of the American Federation of Medical Research (2003) and the Novartis Young Investigator Award for Diabetes Research (2007).

Directors

Nir Barzilai aging research albert einstein college of medicine Montefiore Medical Center Bronx NYNir Barzilai, MD (bio) 

Professor of Medicine
Professor of Genetics
Ingeborg and Ira Leon Rennert Chair in Aging Research
 

 

Ana Maria CuervoAna Maria Cuervo, PhD, MD (bio) 

Professor, Dept. of Molecular Biology
Professor, Dept. of Anatomy & Structural Biology
Professor, Dept. of Medicine
Robert and Renée Belfer Chair for the Study of Neurodegenerative Diseases
 

From the Directors 

 
 
 

Contact Us

Aging Research Center
Albert Einstein College of Medicine
Belfer 701
1300 Morris Park Avenue
Bronx, NY 10461

(718) 430-3144
Fax: (718) 430-8557

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