Institute for Aging Research

Proteostasis of Aging Core

Dr. Ana Maria Cuervo Albert Einstein College of Medicine Montefiore Medical Center Bronx NY

Scientific Director: Ana Maria Cuervo, MD, PhD 


Simoni Tiano

Operations Manager: Simoni Tiano, simoni.tiano@einstein.yu.edu 


The Proteostasis of Aging Core provides state-of-the-art methodology for the study of changes in cellular protein homeostasis in aging and age-related disorders. The core performs highly specialized assays for the analysis of autophagic pathways and the ubiquitin proteasome system and provides advice on experimental design, techniques, and data interpretation in that area.

For information regarding consultation fees, experimental design and methods please contact ana-maria.cuervo@einstein.yu.edu.


Fees (all fees are per assay)

Type of service   NSC member rate   Others  
Protein turnover 
Complete Protein Turnover analysis $600 $950
Protein synthesis (4 samples with triplicates) $200 $300
Protein degradation (1 type sample 6 conditions with triplicates) $500 $600
 Autophagy assays
Macroautophagy (MA)  
LC3 flux - immunoblot (8 conditions) $350 $550
mCherry-GFP-LC3 High content microscopy/96 well plate $600 $800
Mitophagy - immunofluorescence colocalization/8 well $300 $400
Lipophagy - immunofluorescence colocalization/8 well $500 $750
Em morphometric analysis of autophagic compartments*** $200 $300
Chaperone-mediated autophagy (CMA)
KFERQ-Dendra - High content microscopy/96 well plate $600 $800
Lysomal Function  
Lysosomal compartment – Lysotracker/ 8 well $250 $250
Lysosomal markers (panel) - Immunoblot $300 $600
Ubiquitin/Proteasome system assays 
Degron reporter – High content microscopy/ 96 –well plate $650 $950
Consultation
Consultation on study design, methods, interpretation $95/hr $200/hr
Training in proteostasis analysis procedures $50/hr $---
Other Services
Customized analysis of proteostasis Negotiable Negotiable


*** Includes morphometric analysis but excludes fees for sample processing and use of microscopes in the Analytical Imaging Facilities.

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