Research Resource Cores
The aims of the Nathan Shock Center of Excellence in the Biology of Aging are as follows:
- To enhance and expand the ongoing basic biology of aging research in the Institute by establishing 3 research resource cores that are unique (do not exist in other Nathan Shock Centers) and novel (in their use of technology).
- Cellular and Tissue Aging Core (CTAC)
Director: Ana Cuervo, MD
The Cellular and Tissue Aging Core provides current and novel aging-specific measurements of cellular homeostasis as well as molecular modifications of protein, lipid, nucleic acids, and organelles (including assays for mitochondria, lysosomes, and ER function).
- Healthy Aging Physiology Core (HAPC)
Director: Nir Barzilai, MD
The Healthy Aging Physiology Core performs sophisticated integrative metabolic studies in rodents to determine healthy aging physiology such as in vivo whole-body and organ- specific metabolism, body composition and energy balance, exercise, cardiac and cognitive/functional behavior analyses.
- Genomics and Epigenomics of Aging Core (GEAC)
Director: Jan Vijg, PhD
The GEAC provide investigators with whole-genome association data from human centenarians and controls to assess their gene of interest in relationship to human aging and diseases. It provides sequence enrichment for next-generation re-sequencing of candidate gene regions, and genome-wide DNA methylation analysis using advanced high throughput technology.
- To facilitate the planning and coordination of aging biology research activities at Einstein and other regional research institutions by creating an Administrative Core to coordinate activities, foster collaborations and integrate the activities of the Research Resource Cores and related research efforts. This Core will further implement and administer program enhancement through a lecture series and a yearly retreat.
- To provide support and a suitable environment for new investigators in biology of aging research through a Research Development Core that will provide seed funding for new investigators interested in aging research and for expansion of ongoing research programs in exciting new directions. This core will provide mentoring for grant writing through a designated-mentor system, and collaborate (with support from the Aging T32 grant) on course direction for the graduate course in the basic biology of aging.
- To develop potential regional and/or national resource centers, collaborating with leading Biology of Aging investigators from regional and national institutions who will receive discounted Core services and eligibility to compete for E-NSC pilot and feasibility awards.