Office of Grant Support

Block Institute

Block Institute for Clinical and Translational Research at Einstein and Montefiore 



Letter of Intent (required): due January 15, 2014 



SUMMARY: These research career development awards, sponsored by a Clinical and Translational  Science  Award  (CTSA)  from  the  NIH  and  the  Einstein/Montefiore  ICTR,  will provide support for junior faculty (Instructor or Assistant Professor) with doctoral degrees who will devote the majority of their effort to clinical or translational research and training for 2 to 3 years.

Each Scholar must be supervised by a primary mentor, and a formally-designated co-mentor (as described below). Many Scholars will participate in Einstein’s Clinical Research Training Program (CRTP), a CTSA-funded curriculum in clinical research methods leading to the M.S. degree or a similar didactic educational program, either during or prior to this training. Awards provide salary support for the Scholar of up to $75,000 per year (plus fringe), plus up to $15,000 per year for research training and research related expenses.

Full Information about the program can be found at:  


Applicants must have a research or health-professional doctoral degree or its equivalent. Candidates must be able to commit a minimum of 9 calendar months of full-time professional effort  for  career  development  and  research  activities  associated  with  the  program.  The remaining 3 calendar months’ effort can be divided among other research, clinical and teaching activities only if these activities are consistent with the proposed goals of the KL2 program. We encourage applications from members of  underserved and under-represented minority and ethnic populations.

 Applicants  for  KL2  appointments  may  not  simultaneously  submit  or  have  pending  an application for any other PHS mentored career development award (e.g., K07, K08, K22, K23) that duplicates any of the provisions of the KL2 program. Former or current principal investigators on any NIH research project grant (this does not include NIH Small Grants (R03) or Exploratory/ Developmental (R21) grants or their equivalents) or equivalent non - PHS peer reviewed research grants that are over $100,000 direct costs per year, or project  leaders on sub-projects of program project (P01) or center grants (P50) are NOT eligible to participate as KL2 scholars. Appointed KL2 scholars may apply for individual mentored K awards (e.g., K07, K08, K22, K23); if successful, the KL2 appointment would be terminated and funding received from the new individual K award.

Trainees whose primary mentor is a CTSA co-investigator are not eligible.

 Candidates must have the potential to develop into independent clinical or translational investigators. Candidates must have a doctoral degree (eligible doctoral degrees include, but are not limited to, the following: M.D., Ph.D., D.M.D., D.C., D.V.M., O.D., D.P.M., Sc.D., Eng.D., Dr.P.H., D.N.Sc., Pharm.D., D.S.W., Psy.D., as well as a doctoral degree in nursing research or practice), must have completed residency training (or its equivalent) and must be committed to a career in research. Candidates may have initiated clinical specialty or subspecialty training but to be eligible, must devote from 2 to 3 years to this full-time career development program. Candidates selected from this program may be eligible for the Loan Repayment Program (LRP) for clinical investigators that provides for repayment of the educational plan loan debt of physicians and dentists. Information regarding the eligibility requirements and benefits for the program may be obtained via the LRP website (



•    Applicants must be full time employees at Einstein or its affiliated Academic Health Centers, with a faculty appointment at the level of Instructor or Assistant Professor as of the initiation of the award period (July 1, 2014).

•    The proposed research project must fit  within  the rubric  of  clinical  or translational research. “Clinical Research” and “Translational Research” are defined by the NIH, at the following link: Such research must have clear and demonstrable applications to human health and/or disease.

•    Applicants proposing clinical investigation in cancer therapeutics are not eligible

under this funding mechanism. There is a separate mechanism specific for career development in cancer therapeutics, funded by NCI (R. Perez-Soler, PI); eligible candidates should apply directly to that program.

•    Awardees must participate in a monthly workshop, led by faculty of the ICTR, focusing

on their research (e.g., works-in-progress presentations, research methods seminars). The Career Development Plan and the Mentor’s statements should both include an acknowledgment of this requirement; the Mentor’s Statement should specifically indicate that the applicant, if successful, will be given the necessary time to participate. Mentors are strongly encouraged to attend their protégés’ works-in-progress presentations.

•    The  primary  mentor  and  co-mentor  are  required  to  participate  in  a  mentoring development program (details will follow upon receipt of the award). The Mentors’ Statements should indicate that the Mentors agree to participate in the program.


MENTORS: Primary mentors must have full-time faculty appointments at Einstein, and should have  independent  current  NIH  funding  and  a  track  record  of  success  as  a  mentor.  To encourage translational investigation and multidisciplinary mentoring, a Co-Mentor must be named, representing a different discipline from the Primary Mentor. (For example, if the primary mentor is in a clinical discipline, the co-mentor should be in a laboratory or population- based discipline.) We prefer co-mentors from the Einstein faculty, but will accept an extra- institutional co-mentor if adequately justified.

 TERMS OF AWARD: Funding for the Scholar will provide up to $75,000 in salary support (plus fringe benefits). If this amount is insufficient for the proposed time commitment, the Chair’s letter must provide a commitment to provide requisite funding. Applicants are expected to spend at least 75% effort in research and educational activities directly related to the proposed career development program, with an absolute minimum of 50% if sufficiently justified, as described above. Scholars may also request—with adequate justification—modest funding for research training and other research related expenses (up to $15,000 per year). Funding may be requested for a period of 2 - 3 years; funds will be awarded for a one-year period only, with continuation funding contingent upon written demonstration of adequate progress in career development.



The application MUST consist of the following sections (developed to be consistent with the components of an NIH K grant):

1. Introduction to Application (for Resubmissions only, 3 pages max)

2. Candidate’s Background

3. Career Goals and Objectives

4. Career Development/Training Activities During Award Period

5. Training in the Responsible Conduct of Research

6. Specific Aims (1 page max)

7. Research Strategy

8. Statements by Mentor and Co-mentor describing their commitment to the candidate’s career development, their specific role and responsibilities, and an agreement to participate in our mentoring development program.

9. Description of Institutional Environment

10.  Institutional  Commitment  to  Candidate’s  Research  Career  Development  (Letter from Chair)

11. Protection of Human Subjects

12. Inclusion of Women and Minorities

13. Targeted/Planned Enrollment

14. Inclusion of Children

15. Literature Cited

16. Biosketches of Applicant, Mentor, and Co-Mentor (in NIH format)

17. Names and contact information (including fax and email) of 3 potential external

reviewers with expertise in the relevant scientific field.



PAGE LIMITATIONS (note all page limitations refer to single spaced with standard margins and11-point Arial font):

Sections 2 – 5 + 7 are limited to no more than 12 pages in total, with Section 6 limited to one additional page.


For more information on any of these sections, follow the guidance provided by the NIH in the following document (pages I-141 – I-150):


For Section 17, Names, addresses, fax, and email of 3 potential external reviewers:

The Advisory Committee may choose to request up to 3 independent external (i.e., not on the Einstein faculty) reviewers of this application. Potential reviewers should be selected primarily for  their  expertise  in  the  research  proposed;  additionally,  preference  should  be  given  to reviewers who are likely to comply with our request for a brief and rapid review. The review committee may, at its discretion, select additional external reviewers not suggested by the applicant.




Review criteria include:



The Scholar:

•    Scope and quality of clinical and research background;

•    Likelihood of success in a clinical or translational investigative career;

•    Evidence of strong departmental and institutional commitments;

•    Adequacy   of   the   assurance   that   candidate   can   devote   sufficient   effort   to clinical/translational research and training activities throughout the period of this award.



•    A well-developed and feasible interdisciplinary co-mentoring plan;

•    Evidence of understanding of the importance of the mentors’ role;

•    Mentors’ track records of research productivity and funding;

•    Mentors’ track record of mentoring



Career Development Plan:

•    Adequacy of the didactic training in clinical and translational research (For example, the scholar may apply to enroll in the CRTP [information available at]

or provide evidence of other formal ongoing training during the period of award;

•    Adequacy of the nature and duration of research experiences;

•    Adequacy of the nature and duration of any specialized didactic course work, research forums, or research experiences;

•    Evidence of multi-disciplinary training experiences;

•    Appropriate use of Einstein-related resources.



Research Plan:

•    Importance of the research question;

•    Adequacy of the background to support hypotheses;

•    Soundness of the methods;


•    Innovation;

•    Feasibility of the research plan;

•    Likelihood that the research will contribute to a sustainable, independent, investigative career;

•    Evidence  that  the  research  fits  within  the  NIH  definition  of  clinical  research,  or constitutes translational research.


Institutional Environment and Commitment:


•    A  research  environment  likely  to  contribute  to  the  Scholar’s  career  development including (as appropriate) adequate support infrastructure, funding, data, research seminars;

•    Clear evidence of institutional and departmental support, including specific delineation of clinical responsibilities and financial support as needed to meet the requirements of this career development program.






Letter of Intent: a letter of intent is required, and must be submitted on or before January 15, 2014. The letter of intent must include the following information:

•    Applicant’s name, department(s), and faculty rank;

•    Mentor’s name, department(s), and faculty rank;

•    Co-mentor’s name, department(s), and faculty rank; and

•    Title of proposed project (providing information on content area and research approach) Letters of intent should be submitted via email to


 Applications must be formatted by the applicant into a single document PDF format. The application must be submitted through our web-based submission system NO LATER THAN NOON on February 17, 2014 through the portal at:



Administrative questions should be addressed to Ms. Merrilly Calabrese,, or 718-430-3234. Programmatic questions should be addressed to Paul Marantz, MD, MPH, Associate Dean for Clinical Research Education,, or 718-430-4187.

Click here to log in