Institutional Animal Care and Use Committee

Policy No.2011-1: Standard Operating Procedure for Use of Core Services for Non-Einstein Animal Users

Reapproved: June 15, 2011

Non-Einstein Investigators may request the import of animals from their institution to Albert Einstein College of Medicine (Einstein) for scientific core services (i.e. Behavioral Evaluation, Gruss Magnetic Resonance Research Center, Histotechnology and Comparative Pathology, Positron Emission Tomography (MicroPET), Transgenic and Gene Targeting, etc.) studies.

Required Documents

  1. Protocol Approval: The protocol for Einstein core services for Non-Einstein Investigators must be approved by the specific core director and/or core protocol review committee before submission to the Einstein IACUC. Non-Einstein Investigators must provide current copies of all relevant Institutional Animal Care and Use Committee (IACUC) - or equivalent committee - protocol(s) approved by their institution. The protocol must include the procedure to be performed at Einstein and any anesthesia, analgesia, and recovery plan. If the project will be a collaboration and not just fee for service, an Einstein animal use protocol is required. The Einstein animal use protocol will be prepared with assistance from Einstein scientific core staff and must be reviewed and approved by Einstein’s IACUC before importation and scheduling of core services. If any animal housing requirements are anticipated, the Einstein veterinary staff will review housing requirements. If animals will be returning to the Non-Einstein Investigator’s animal facility, approval permitting the animals to be away from their housing facility for the duration of the time at Einstein’s core laboratory and return to their housing facility must be provided by the Non-Einstein Investigator’s institution.
  2. Health Report: A health report is required for all animals that will be brought to Einstein. The report must reflect the current status of the sending institution's animal colony. Data must be from within the last 4 months. Einstein’s veterinary staff will review the report, and approve or reject the animals for shipment. If approved for receipt, the veterinary care staff and Einstein’s core service staff will arrange/coordinate transportation of the animals from the external institution to the core laboratory at Einstein.
 

Transportation/Importation

It is the responsibility of the sending institution/Non-Einstein Investigator to provide animal transport. Transport vehicles must be climate controlled. Rodents must be transported in approved filtered shipping containers.

  1. Shipments of animals that will be killed within 12 hours of arrival are imported as described in Appendix 1. Approved studies will be performed in the core facility and animals will be sacrificed at the end of the study (within 12 hours).
  2. Animals that will be housed at Einstein for an extended period of time are imported following the policy of Einstein’s Institute for Animal Studies (IAS) for importation and quarantine as described in Appendix 3.
  3. Animals that will be temporarily housed within core facilities while undergoing core procedures are imported as described in Appendix 2. Approved studies will be performed in the core laboratory and animals will be temporarily housed in the core as approved by the Einstein IACUC.
  4. In all cases a “Request to Import Animals from Another Institution” (Appendix 4) must be filled out.
 

Standard Practices to Minimize Contamination

It is the responsibility of the core staff to prepare the core laboratory and environment to receive the imported animals and minimize any possible cross contaminations between Einstein animals and non-Einstein animals. This will include cleaning and preparing temporary animal housing, imaging or behavioral testing equipment, lab benches, animal anesthesia nose cones, induction boxes and restrainers, and any surfaces that come into contact with the animals during the procedures.

If the rodents are to be housed temporarily, overnight or for a short term in the core, arrangements must be made with the core and approved by Einstein’s IACUC and an Institute for Animal Studies’ veterinarian. The core staff will be responsible for the daily health checks of the animals. Every effort will be made to isolate the non-Einstein animals while they are at the core laboratory. However, there is no complete guarantee that the health status of the non-Einstein animals will be maintained. It is recommended that animals returning to the Non-Einstein Investigator’s institution be quarantined upon arrival.

Once studies in the core are completed the core lab will be cleaned as above and all surfaces coming into contact with the non-Einstein animals will be disinfected as approved by Einstein’s Institute for Animal Studies. No Einstein animals will be allowed into the core facility until the cleanup has been completed. Any carcasses of non-Einstein animals must be disinfected and bagged and sealed prior to disposal.

For Appendices, please download MS Word Version of Policy.

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